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1

Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B

Christopher E. Westland, Huiling Yang, William E. Delaney IV, Craig S. Gibbs, Michael D. Miller, Michael Wulfsohn, John Fry, Carol L. Brosgart, Shelly Xiong

Journal:

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

2

Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil

Chris Westland, William Delaney IV, Huiling Yang, Shan-shan Chen, Patrick Marcellin, Stephanos Hadziyannis, Robert Gish, John Fry, Carol Brosgart, Craig Gibbs, Michael Miller, Shelly Xiong

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 323 KB

english, 2003

3

Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes

Josef Köck, Thomas F. Baumert, William E. Delaney IV, Hubert E. Blum, Fritz von Weizsäcker

Journal:

Year:

2003

Language:

english

File:

PDF, 273 KB

english, 2003

4

Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors

X. Christopher Sheng, Hyung-Jung Pyun, Kleem Chaudhary, Jianying Wang, Edward Doerffler, Melissa Fleury, Darren McMurtrie, Xiaowu Chen, William E. Delaney IV, Choung U. Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 683 KB

english, 2009

5

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease

Michael O. Clarke, Xiaowu Chen, Aesop Cho, William E. Delaney IV, Edward Doerffler, Maria Fardis, Mingzhe Ji, Michael Mertzman, Rowchanak Pakdaman, Hyun-Jun Pyun, Tanisha Rowe, Cheng Y. Yang, X. Chris

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 542 KB

english, 2011

6

Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients

C. E. Westland, H. Yang, W. E. Delaney IV, M. Wulfsohn, N. Lama, C. S. Gibbs, M. D. Miller, J. Fry, C. L. Brosgart, E. R. Schiff, S. Xiong

Journal:

Journal of Viral Hepatitis

Year:

2005

Language:

english

File:

PDF, 69 KB

english, 2005

7

Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model

James R Jacob, Brent E Korba, Paul J Cote, Ilia Toshkov, William E Delaney IV, John L Gerin, Bud C Tennant

Journal:

Antiviral Research

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

8

In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector

Huiling Yang, Christopher Westland, Shelly Xiong, William E Delaney IV

Journal:

Antiviral Research

Year:

2004

Language:

english

File:

PDF, 389 KB

english, 2004

9

Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus

Matthew S. Paulson, Huiling Yang, I-hung Shih, Joy Y. Feng, Eric M. Mabery, Margaret F. Robinson, Weidong Zhong, William E. Delaney IV

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 544 KB

english, 2009

10

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

X. Christopher Sheng, Anthony Casarez, Ruby Cai, Michael O. Clarke, Xiaowu Chen, Aesop Cho, William E. Delaney IV, Edward Doerffler, Mingzhe Ji, Michael Mertzman, Rowchanak Pakdaman, Hyung-Jung Pyun,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 344 KB

english, 2012

11

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

X. Christopher Sheng, Todd Appleby, Thomas Butler, Ruby Cai, Xiaowu Chen, Aesop Cho, Michael O. Clarke, Jeromy Cottell, William E. Delaney IV, Edward Doerffler, John Link, Mingzhe Ji, Rowchanak Pakdam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

12

An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture

Katie Chan, Guofeng Cheng, Rudolf K.F. Beran, Huiling Yang, Todd C. Appleby, Maria V. Pokrovskii, Hongmei Mo, Weidong Zhong, William E. Delaney IV

Journal:

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

13

Therapy of chronic hepatitis B: trends and developments

William E Delaney IV, Katyna Borroto-Esoda

Journal:

Current Opinion in Pharmacology

Year:

2008

Language:

english

File:

PDF, 432 KB

english, 2008

14

382 In vitro characterization and molecular modeling analysis of a novel adefovir resistance mutation RTN236T in the HBV polymerase

H. Yang, X. Qi, K. Das, E. Arnold, C.E. Westland, W.E. Delaney IV, C.L. Brosgart, C.S. Gibbs, M.D. Miller, S. Xiong

Journal:

Journal of Hepatology

Year:

2004

Language:

english

File:

PDF, 64 KB

english, 2004

15

P.159 A novel fluorescence-based protease assay using the endogenous NS3/4A protease activity present in the total cell lysates of HCV replicon cells

H. Yang, W.E. Delaney IV

Journal:

Journal of Clinical Virology

Year:

2006

Language:

english

File:

PDF, 281 KB

english, 2006

16

Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy

Bettina Werle–Lapostolle, Scott Bowden, Stephen Locarnini, Karsten Wursthorn, Jorg Petersen, George Lau, Christian Trepo, Patrick Marcellin, Zachary Goodman, William E. Delaney IV, Shelly Xiong, Carol

Journal:

Gastroenterology

Year:

2004

Language:

english

File:

PDF, 243 KB

english, 2004

17

Lack of emerging resistance mutations in 467 HBeAg− and HBeAg+ patients with chronic hepatitis B receiving Adefovir Dipivoxil for 48 weeks

Huiling Yang, Christopher Westland, William Delaney IV, Craig Gibbs, Michael Miller, John Fry, Carol Brosgart, Shelly Xiong

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 221 KB

english, 2002

18

Resistance profile of adefovir dipivoxil (ADV) in immunocompetent and immunocompromised chronic hepatitis B patients after 48 weeks of adefovir dipivoxil therapy

C.E. Westland, H. Yang, W.E. Delaney IV, V. Thibault, Y. Benhamou, C.S. Gibbs, M.D. Miller, M. Wulfsohn, M. Sullivan, J. Fry, C.L. Brosgart, S. Xiong

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 162 KB

english, 2003

19

Efficient in vitro phenotypic analysis of full lengrh clinical HBV isolates using a novel expression vector

H. Yang, S. Xiong, W.E. Delaney IV

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

20

Comparison of viral replication fitness of wild-type and lamivudine-resistant HBV in patients

W.E. Delaney IV, C. Westland, H. Yang, H. Namini, V. Thibault, Y. Benhamou, J. Fry, C. Brosgart, C. Gibbs, M. Miller, S. Xiong

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 319 KB

english, 2003

21

Resistance surveillance of HBEAG— chronic hepatitis B (CHB) patients treated for two years with adefovir dipivoxil (ADV)

S. Xiong, H. Yang, C.E. Westland, W.E. Delaney IV, D. Colledge, A. Bartholomeusz, V. Thibault, Y. Benhamou, P. Angus, M. Wulfsohn, C.S. Gibbs, J. Fry, C.L. Brosgart, S. Locarnini

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 162 KB

english, 2003

22

Development of Robust Hepatitis C Virus Genotype 4 Subgenomic Replicons

Betty Peng, Mei Yu, Simin Xu, Yu–Jen Lee, Yang Tian, Huiling Yang, Katie Chan, Hongmei Mo, John McHutchison, William Delaney IV, Guofeng Cheng

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

23

MITRAL INCOMPETENCE

Chan, Katie, Robinson, Margaret, Yang, Huiling, Cornew, Sophia, Delaney IV, William E.

Journal:

Year:

1953

Language:

english

File:

PDF, 417 KB

english, 1953

24

Development of a robust luciferase reporter 1b/2a hepatitis C virus (HCV) for characterization of early stage HCV life cycle inhibitors

Chan, Katie, Robinson, Margaret, Yang, Huiling, Cornew, Sophia, Delaney IV, William E.

Journal:

Antiviral Research

Year:

2013

Language:

english

File:

PDF, 472 KB

english, 2013

25

Positions available

Chan, Katie, Robinson, Margaret, Yang, Huiling, Cornew, Sophia, Delaney IV, William E.

Journal:

Year:

1983

Language:

english

File:

PDF, 105 KB

english, 1983

26

Comparison of Viral replication fitness of wild-type and lamivudine-resistant HBV in patients

Iv, William Delaney, Westland, Christopher, Yang, Huiling, Namini, Hamid, Thibault, Vincent, Benhamou, Yves, Brosgart, Carol, Gibbs, Craig, Miller, Michael, Xiong, Shelly

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 252 KB

english, 2003

27

Evolving therapies for the treatment of chronic hepatitis B virus infection

IV, William E Delaney, Bartholomeusz, Angeline, Locarnini, Stephen A

Journal:

Expert Opinion on Investigational Drugs

Year:

2002

Language:

english

File:

PDF, 317 KB

english, 2002

28

Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals

Margaret Robinson, Yang Tian, William E. Delaney IV and Andrew E. Greenstein

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

29

Preclinical characterization of the novel HCV NS3 protease inhibitor GS-9256

Yang, Huiling, Yang, Chris, Wang, Yujin, Rhodes, Gerry, Robinson, Margaret, Cheng, Guofeng, Qi, Xiaoping, Mo, Hongmei, Tian, Yang, Pakdaman, Rowchanak, Sheng, X Christopher, Kim, Choung U, Delaney IV,

Journal:

Antiviral Therapy

Year:

2017

Language:

english

File:

PDF, 319 KB

english, 2017